Dr. Hongwei Gai is a professor ofSchool of Chemistry and Materials Science at Jiangsu Normal University sinceDec. 2011. He earned his doctorate degree in analytical chemistry at ChineseScience of Academy, Dalian Institute of Chemical Physics in 2005. After he did his postdoctoralwork in Health ScienceCenter at TexasUniversity in San Antonio, Dr. Gai joined Biomedical Engineering Center at Hunan Universityas an appointed professor in Dec. 2006. Dr. Gai became a full professor in Aug.2009 and then in School of Biology after Jan.2010.
Dr. Gai’s research focuseson single molecule fluorescence imaging and the application in chemistry andbiology. Dr. Gai has published over 40 scientific papers most in the journalslike Anal Chem， Lab Chip， Chem Commun， Angew Chem Int Ed, and he holds five patents. Dr. Gai receivedYoung Scholar and General Project from National Natural Science Foundation.
姓 名：盖宏伟
学位学历：博士研究生
职称：教授
职务：科学技术研究院副院长
学科专业：分析化学
E-mail：gai@jsnu.edu.cn
【个人简历】
1.教育背景和工作简历
1993年9月- 1997年7月:西安交通大学，化工学院，学士
1997年9月- 2000年7月:大连理工大学，化工学院，硕士
2000年9月- 2005年11月:中国科学院大连化学物理研究所，分析化学，博士
2005年11月－2006年10月：美国德州大学圣安东尼奥健康科学中心，博士后
2006年10月－2011年11月：湖南大学生物医学工程中心/生物学院，校聘教授/教授
2011年12月至今：江苏师范大学，化学与材料科学学院，教授
2013年4月-2018年7月：江苏师范大学化学与材料科学学院，副院长
2018.4月至今：江苏师范大学科学技术研究员，副院长
2.工作成绩及学术成果。
已发表SCI收录学术论文45篇，多数发表于AnalChem， Lab Chip， Chem Commun， Angew Chem Int Ed等国际著名刊物。申请发明专利十余项，已授权五项。主持国家自然科学基金面上项目2项、青年项目1项， 江苏省高校自然科学研究重大项目1项，湖南省科技厅项目2项，江苏省高校“青蓝工程”中青年学术带头人，江苏省第五期“333高层次人才培养工程”第三层次，江苏省“六大人才高峰”高层次人才。第十一届江苏省青年联合会委员。第九届徐州市云龙区政协委员。
【研究领域和兴趣】
主要从事单分子荧光检测研究。以显微成像为主要手段，在细胞和单分子层面上，开展以高灵敏检测和动态监测为特征的疾病早期诊断和致病机理研究，包括单分子单颗粒传感，动态单分子间相互作用的监测，纳米显微技术等。
【成绩及获奖情况】
1. 2018年淮海科学技术奖励，一等奖
2. 2018年江苏省分析测试科学技术奖，二等奖
3. 2018年大连市科学技术奖励，一等奖（排名第三）
4. 2018年江苏省教育教学与研究成果奖（研究类），三等奖
5. 2011年大连市科学技术奖励，二等奖（排名第二）
6. 2010年湖南省化学化工协会青年化学奖
【承担的主要科研项目】
序号 | 项目名称 | 项目级别 | 项目来源 | 项目号 | 项目排序 | 起止日期 |
1 | 高分辨光流控显微成像技术及应用研究 | 国家 | 国家自然科学基金 | 21575053 | 1 | 2016.1-2019.12 |
2 | 单分子远场三维纳米成像技术 | 国家 | 国家自然科学基金 | 21075033 | 1 | 2011.1-2013.12 |
3 | 高量单分通子微阵列芯片 | 国家 | 国家自然科学基金 | 20705007 | 1 | 2008.1-2010.12 |
4 | 基于单分子微阵列芯片的肺癌骨髓微转移研究 | 省级 | 湖南省科技厅 | 2008WK3004 | 1 | 2008.12-2009.12 |
5 | 微芯片上的无透镜显微成像系统 | 省级 | 湖南省科技厅 | 2011TT2026 湘科条字【2011】128号 | 1 | 2012.1－2012.12 |
6 | 江苏省高校“青蓝工程”中青年学术带头人 | 省级 | 江苏省教育厅 |
| 1 | 2013.1-2015.12 |
7 | 江苏省高校自然科学研究重大项目 | 省级 | 江苏省教育厅 | 16KJA150006 | 1 | 2016.9-2019.12 |
8 | 江苏省“六大人才高峰”高层次人才 | 省级 | 江苏省人力资源和社会保障厅 |
| 1 | 2017.1－2018.12 |
9 | 江苏省第五期“333高层次人才培养工程”第三层次 | 省级 | 江苏省人才办 |
| 1 | 2017.1－2018.12 |
【代表论文】
33. QingquanZhang, Xuebing Zhang, Jiajia Li, HongweiGai*, Non-stochastic protein counting analysis for precision biomarkerdetection: suppressing Poisson noise at ultralow concentration, AnalyticalChemistry, 2020, Anal Chem 2020, 92, 654−658.
32. QingquanZhang, Jiaqu Chen, Hongwei Gai*,High-throughput-generating water-in-water droplet for monodispersebiocompatible particle synthesis, Journal of Materials Science, 2019, 54,14905-14913.
31. XiaojunLiu, Yusu Zhang, Aiye Liang, Hongwei Ding, HongweiGai*，Plasmonic resonanceenergy transfer from a Au nanosphere to quantum dots at a single particle leveland its homogenous immunoassay, Chemical Communications, 2019, 55, 11442-11445.
30． XiaojunLiu, Conghui Huang, Chenghua Zong, Aiye Liang, Zhangjian Wu, Yusu Zhang,Qingquan Zhang, Wenfeng Zhao, HongweiGai *,A Single-MoleculeHomogeneous Immunoassay by Counting Spatially “Overlapping” Two-Color QuantumDots with Wide-Field Fluorescence Microscopy, ACS Sensors, 2018,3, 2644-2650.
29． XiaojunLiu, Conghui Huang, Xiuling Dong, Aiye Liang, Yusu Zhang, Qingquan Zhang, QiWang*, Hongwei Gai *, Asynchronyof spectral blue-shifts of quantum dot based digital homogeneous immunoassay, ChemicalCommunications, 2018, 54, 13103-13106.
28．Suli Dong,Xiaojun Liu, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong, Aiye Liang, Hongwei Gai *, Sensing activeheparin by counting aggregated quantum dots at single-particle level, ACSSensors, 2017, 2, 80-86.
27. QiangquanZhang, Hanlin Li, Xiaojun Liu, Wenfeng Zhao, Chenghua Zong, Hongwei Gai *, A self-drivenminiaturized liquid fuel cell, Chemical Communications, 2016, 52, 12068-12071.
26. QingquanZhang, Meng Xu, Xiaojun Liu, Wenfeng Zhao, Chenghua Zong, Yang Yu, Qi Wang *,Hongwei Gai*, Fabrication of Janus droplets by evaporation driven liquid-liquidphase separation, Chemical Communications, 2016, 52, 5015-5018.
25. XiaojunLiu, Zhangjian Wu, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong, Hongwei Gai*,Single Gold Nanoparticle-Based Colorimetric Detection of Picomolar Mercury Ionwith Dark-Field Microscopy, Analytical Chemistry, 2016, 88, 2119-2124.
24. WenfengZhao*, Wei Jia, Mimi Sun, Xiaojun Liu, Qingquan Zhang, Chenghua Zong, HongweiGai*, Colorimetric detection of Cu 2+ by surface coordination complexes ofpolyethyleneimine-capped Au nanoparticles, Sensors and Actuators: B. Chemical,2016, 223, 411-416.
23.Xiaojun Liu, Yawei Wang, Yang Tu, Ziqi Zhu, Xiaogang Li, Qingquan Zhang,Wenfeng Zhao, Yuling Li, Hongwei Gai*, A rapid and simple approach forglycoform analysis, Analytica Chimica Acta, 2015, 865,71-75.
22. XingboShi, Suli Dong, Minmin Li, Xiaojun Liu, Qingquan Zhang, Wenfeng Zhao, ChenghuaZong, Yewang Zhang, Hongwei Gai*, Counting quantum dot aggregates for thedetection of biotinylated proteins, Chemical Communications, 2015, 51,2353-2356.
21. XingboShi, Minmin Li, Wenfeng Zhao, Aiye Liang , Xiaojun Liu, Hongwei Gai*, Spectralimaging superlocalization microscopy for quantum dots, Sensors and Actuators:B. Chemical, 2015, 207, 308-312.
20. WenfengZhao, Suli Dong, Lichun Sun, Qi Wang*, Hongwei Gai*, Investigating thePhotostability of Quantum Dots at the Single-Molecule Level, Chemistry-An AsianJournal, 2014, 9, 3542-3548.
19.Qingquan Zhang, Xiaojun Liu, Dayu Liu, Hongwei Gai*, Ultra small dropletgeneration via volatile component evaporation, Lab on a Chip, 2014, 14(8), 1395- 1400.
18. XiaojunLiu, Qingquan Zhang, Yang Tu, HongweiGai*, Single Gold Nanoparticle Localized Surface Plasmon Resonance SpectralImaging for Quantifying Binding Constant of Carbohydrate–Protein Interaction,Analytical Chemistry, 2013, 85, 11851–11857.
17. Xingbo Shi, Yang Tu, Xiaojun Liu, Edward SYeung, Hongwei Gai*, Photobleaching of Quantum Dots by Non-resonant Light,Physical Chemistry Chemical Physics, 2013, 15, 3130-3132.
16.刘晓君，涂洋，盖宏伟*，单分子宽场光学显微成像技术，化学进展，2013，25，370-379.
15.Xiaojun Liu, Hui Wang, Aiye Liang, Yuling Li,Hongwei Gai*, Bingcheng Lin*, Determination of binding constants between 1 oneprotein and multiple carbohydrates by affinity chromatography on a microchip,Journal of Chromatography A, 2012, 1270,340-343.
14.Xingbo Shi, Zhongqiu Xie, Yuehong Song,Yongjun Tan, Edward S. Yeung, Hongwei Gai*, Super-Localization Spectral ImagingMicroscopy of Multi-color Quantum Dot Complex, Analytical Chemistry , 2012,84(3),1504-1509.
13.Linfen Yu, Qun Li, Hongwei Gai*, ZhanhuiWang*, Chemiluminescence Response of Murine Macrophages on MultilayerMicrofluidic Chips, Appl. Biochem. Biotechnol., 2012, 166, 786-795.
12.Hongwei Gai*, Yongjun Li*, Edward S Yeung,Optical detection system of microfluidic chip, Topics in Current Chemistry，2011，304:171-201
11.Xingbo Shi, Xianxin Meng, Lichun Sun, JinhuaLiu, Jing Zheng, Hongwei Gai*, Ronghua Yang, Edward S Yeung, Observingphotophysical properties of quantum dots in air at the single molecule level:advantages in microarray applications, Lab on a Chip, 2010, 10, 2844-2847.(Outside front cover)
10.Xiaobing Bu, Huaping Chen, Hongwei Gai*,Ronghuang Yang, Edward S Yeung, Scattering imaging of single quantum dots withdark-field microscopy, Analytical Chemistry, 2009, 81, 7507-7509.
9. Nan Li, Hui Tang, Hongwei Gai,* Xiuling Dong,Qi Wang, Edward S Yeung, Determination of protein surface excess on aliquid/solid interface by single-molecule counting, Analytical andBioanalytical Chemistry, 2009, 394, 1879-1885.
8.Huaping Chen, Hongwei Gai,* Edward S Yeung,Inhibition of Photobleaching and Blue Shift in Quantum Dots, ChemicalCommunications, 2009, 1676-1678.
7.Rui Han, Yewang Zhang, Xiuling Dong, HongweiGai*, Edward Yeung, Spectral imaging of single molecules by transmissiongrating-based epi-fluorescence microscopy, Analytica Chimica Acta, 2008, 619,209-214.
6.Qun Li, Rui Han, Xianxin Meng, Hongwei Gai*,Edward Yeung, Tracking single quantum dot and its spectrum in free solutionwith controllable thermal diffusion suppression, Analytical Biochemistry, 2008,377 , 176–181
5. Hongwei Gai, Isaac Stayton, Xin Liu,Bingcheng Lin, Yinfa Ma, Visualizing chemical interactions in life scienceswith wide-field fluorescence microscopy towards the single-molecule level,Trends in Analytical Chemistry, 2007, 26, 980-992.
4. HongweiGai, Gary A. Griess, Borries Demeler, Susan T. Weintraub, Philip Serwer,Routine fluorescence microscopy of single untethered protein molecules confinedto a planar zone, Journal of Microscopy, 2007, 226, 256–262.
3.Hongwei Gai, Qi Wang, Yinfa Ma, BingchengLin, Correlations between molecular numbers and molecular masses in anevanescent field and their applications in probing molecular interactions.Angewandte Chemie International Edition, 2005, 44, 5107-5110.
2.Hongwei Gai, Ying Li, Zhan-Hua Silber-Li,Yinfa Ma, Bingcheng Lin, Simultaneously measurements of bulk flow and near wallflow velocity in a microchannel at single molecule level, Lab on a Chip, 2005,5, 443-449.
1.Hongwei Gai, Linfen Yu, Zhongpeng Dai, YinfaMa, Bingcheng Lin., Injection by Hydrostatic Pressure Conjunction withElectrokinetic Force on a Microfluidic Chip, Electrophoresis, 2004,25,1888-1894.
